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Portait Tobias Rose

Tobias Rose

Professor

  • tobias.rose@ukbonn.de
  • +49 228 287 62290
  • https://www.troselab.de
  • Institute of Experimental Epileptology and Cognition ResearchUniversity of Bonn Medical Center Life and Brain Center (Building 76) Venusberg-Campus 1 53127 Bonn, Germany

Tobias Rose

Professor

Our research addresses the stability-plasticity conundrum in the mouse visual system, dorsal cortex, thalamus, and hippocampal formation. We combine densely quantified closed-loop behavior, longitudinal optophysiology from synapses to circuits, and computational modeling across timescales from milliseconds to months. Current work focuses on representational drift and feedback stabilization, spatial and contextual memory representations in retrosplenial cortex, active sensing during visual orienting, and uncertainty-dependent neuromodulation. Across these themes, we build technology and analysis frameworks that link circuit dynamics to adaptive behavior in naturalistic conditions.

Publications

2025

Katzner, Steffen; Rose, Tobias; Tchumatchenko, Tatjana; Busse, Laura

The Role of Layer 6 Corticothalamic Circuits in Vision: Plasticity, Sensory Processing, and Behavior Journal Article

In: Annual Review of Vision Science, 2025.

Links | BibTeX

@article{Katzner2025The,
title = {The Role of Layer 6 Corticothalamic Circuits in Vision: Plasticity, Sensory Processing, and Behavior},
author = {Steffen Katzner and Tobias Rose and Tatjana Tchumatchenko and Laura Busse},
url = {https://doi.org/10.1146/annurev-vision-101322-012348},
doi = {10.1146/annurev-vision-101322-012348},
year = {2025},
date = {2025-09-01},
journal = {Annual Review of Vision Science},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1146/annurev-vision-101322-012348
  • doi:10.1146/annurev-vision-101322-012348

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2024

Bauer, Joel; Lewin, Uwe; Herbert, Elizabeth; Gjorgjieva, Julijana; Schoonover, Carl E.; Fink, Andrew J. P.; Rose, Tobias; Bonhoeffer, Tobias; Hübener, Mark

Sensory experience steers representational drift in mouse visual cortex Journal Article

In: Nature Communications, 2024.

Links | BibTeX

@article{Bauer2024Sensory,
title = {Sensory experience steers representational drift in mouse visual cortex},
author = {Joel Bauer and Uwe Lewin and Elizabeth Herbert and Julijana Gjorgjieva and Carl E. Schoonover and Andrew J. P. Fink and Tobias Rose and Tobias Bonhoeffer and Mark Hübener},
url = {https://doi.org/10.1038/s41467-024-53326-x},
doi = {10.1038/s41467-024-53326-x},
year = {2024},
date = {2024-10-01},
journal = {Nature Communications},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1038/s41467-024-53326-x
  • doi:10.1038/s41467-024-53326-x

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Kremers, Leon; Rose, Tobias

Feedback needs experience Journal Article

In: Neuron, 2024.

Links | BibTeX

@article{Kremers2024Feedback,
title = {Feedback needs experience},
author = {Leon Kremers and Tobias Rose},
url = {https://doi.org/10.1016/j.neuron.2024.09.016},
doi = {10.1016/j.neuron.2024.09.016},
year = {2024},
date = {2024-10-01},
journal = {Neuron},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1016/j.neuron.2024.09.016
  • doi:10.1016/j.neuron.2024.09.016

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2022

Timón, Laura Bernáez; Ekelmans, Pierre; Kraynyukova, Nataliya; Rose, Tobias; Busse, Laura; Tchumatchenko, Tatjana

How to incorporate biological insights into network models and why it matters Journal Article

In: The Journal of Physiology, 2022.

Links | BibTeX

@article{Timón2022How,
title = {How to incorporate biological insights into network models and why it matters},
author = {Laura Bernáez Timón and Pierre Ekelmans and Nataliya Kraynyukova and Tobias Rose and Laura Busse and Tatjana Tchumatchenko},
url = {https://doi.org/10.1113/JP282755},
doi = {10.1113/JP282755},
year = {2022},
date = {2022-09-01},
journal = {The Journal of Physiology},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1113/JP282755
  • doi:10.1113/JP282755

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Weiler, Simon; Nilo, Drago Guggiana; Bonhoeffer, Tobias; Hübener, Mark; Rose, Tobias; Scheuss, Volker

Functional and structural features of L2/3 pyramidal cells continuously covary with pial depth in mouse visual cortex Journal Article

In: Cerebral Cortex, 2022.

Links | BibTeX

@article{Weiler2022Functional,
title = {Functional and structural features of L2/3 pyramidal cells continuously covary with pial depth in mouse visual cortex},
author = {Simon Weiler and Drago Guggiana Nilo and Tobias Bonhoeffer and Mark Hübener and Tobias Rose and Volker Scheuss},
url = {https://doi.org/10.1093/cercor/bhac303},
doi = {10.1093/cercor/bhac303},
year = {2022},
date = {2022-08-01},
journal = {Cerebral Cortex},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1093/cercor/bhac303
  • doi:10.1093/cercor/bhac303

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Weiler, Simon; Nilo, Drago Guggiana; Bonhoeffer, Tobias; Hübener, Mark; Rose, Tobias; Scheuss, Volker

Orientation and direction tuning align with dendritic morphology and spatial connectivity in mouse visual cortex Journal Article

In: Current Biology, 2022.

Links | BibTeX

@article{Weiler2022Orientation,
title = {Orientation and direction tuning align with dendritic morphology and spatial connectivity in mouse visual cortex},
author = {Simon Weiler and Drago Guggiana Nilo and Tobias Bonhoeffer and Mark Hübener and Tobias Rose and Volker Scheuss},
url = {https://doi.org/10.1016/j.cub.2022.02.048},
doi = {10.1016/j.cub.2022.02.048},
year = {2022},
date = {2022-04-01},
journal = {Current Biology},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1016/j.cub.2022.02.048
  • doi:10.1016/j.cub.2022.02.048

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Obenhaus, Horst A.; Zong, Weijian; Jacobsen, R. Irene; Rose, Tobias; Donato, Flavio; Chen, Liangyi; Cheng, Heping; Bonhoeffer, Tobias; Moser, May-Britt; Moser, Edvard I.

Functional network topography of the medial entorhinal cortex Journal Article

In: Proceedings of the National Academy of Sciences, 2022.

Links | BibTeX

@article{Obenhaus2022Functional,
title = {Functional network topography of the medial entorhinal cortex},
author = {Horst A. Obenhaus and Weijian Zong and R. Irene Jacobsen and Tobias Rose and Flavio Donato and Liangyi Chen and Heping Cheng and Tobias Bonhoeffer and May-Britt Moser and Edvard I. Moser},
url = {https://doi.org/10.1073/pnas.2121655119},
doi = {10.1073/pnas.2121655119},
year = {2022},
date = {2022-02-01},
journal = {Proceedings of the National Academy of Sciences},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1073/pnas.2121655119
  • doi:10.1073/pnas.2121655119

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2021

Bauer, Joel; Weiler, Simon; Fernholz, Martin H. P.; Laubender, David; Scheuss, Volker; Hübener, Mark; Bonhoeffer, Tobias; Rose, Tobias

Limited functional convergence of eye-specific inputs in the retinogeniculate pathway of the mouse Journal Article

In: Neuron, 2021.

Links | BibTeX

@article{Bauer2021Limited,
title = {Limited functional convergence of eye-specific inputs in the retinogeniculate pathway of the mouse},
author = {Joel Bauer and Simon Weiler and Martin H. P. Fernholz and David Laubender and Volker Scheuss and Mark Hübener and Tobias Bonhoeffer and Tobias Rose},
url = {https://doi.org/10.1016/j.neuron.2021.05.036},
doi = {10.1016/j.neuron.2021.05.036},
year = {2021},
date = {2021-08-01},
journal = {Neuron},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1016/j.neuron.2021.05.036
  • doi:10.1016/j.neuron.2021.05.036

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2018

Rose, Tobias; Bonhoeffer, Tobias

Experience-dependent plasticity in the lateral geniculate nucleus Journal Article

In: Current Opinion in Neurobiology, 2018.

Links | BibTeX

@article{Rose2018Experiencedependent,
title = {Experience-dependent plasticity in the lateral geniculate nucleus},
author = {Tobias Rose and Tobias Bonhoeffer},
url = {https://doi.org/10.1016/j.conb.2018.04.016},
doi = {10.1016/j.conb.2018.04.016},
year = {2018},
date = {2018-12-01},
journal = {Current Opinion in Neurobiology},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1016/j.conb.2018.04.016
  • doi:10.1016/j.conb.2018.04.016

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Weiler, Simon; Bauer, Joel; Hübener, Mark; Bonhoeffer, Tobias; Rose, Tobias; Scheuss, Volker

High-yield in vitro recordings from neurons functionally characterized in vivo Journal Article

In: Nature Protocols, 2018.

Links | BibTeX

@article{Weiler2018Highyield,
title = {High-yield in vitro recordings from neurons functionally characterized in vivo},
author = {Simon Weiler and Joel Bauer and Mark Hübener and Tobias Bonhoeffer and Tobias Rose and Volker Scheuss},
url = {https://doi.org/10.1038/nprot.2018.026},
doi = {10.1038/nprot.2018.026},
year = {2018},
date = {2018-05-01},
journal = {Nature Protocols},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1038/nprot.2018.026
  • doi:10.1038/nprot.2018.026

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2017

Jaepel, Juliane; Hübener, Mark; Bonhoeffer, Tobias; Rose, Tobias

Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice Journal Article

In: Nature Neuroscience, 2017.

Links | BibTeX

@article{Jaepel2017Lateral,
title = {Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice},
author = {Juliane Jaepel and Mark Hübener and Tobias Bonhoeffer and Tobias Rose},
url = {https://doi.org/10.1038/s41593-017-0021-0},
doi = {10.1038/s41593-017-0021-0},
year = {2017},
date = {2017-11-01},
journal = {Nature Neuroscience},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1038/s41593-017-0021-0
  • doi:10.1038/s41593-017-0021-0

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Rose, Tobias; Hübener, Mark

Synapses get together for vision Journal Article

In: Nature, 2017.

Links | BibTeX

@article{Rose2017Synapses,
title = {Synapses get together for vision},
author = {Tobias Rose and Mark Hübener},
url = {https://doi.org/10.1038/nature23098},
doi = {10.1038/nature23098},
year = {2017},
date = {2017-07-01},
journal = {Nature},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1038/nature23098
  • doi:10.1038/nature23098

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Clopath, Claudia; Bonhoeffer, Tobias; Hübener, Mark; Rose, Tobias

Variance and invariance of neuronal long-term representations Journal Article

In: Philosophical Transactions of the Royal Society B: Biological Sciences, 2017.

Links | BibTeX

@article{Clopath2017Variance,
title = {Variance and invariance of neuronal long-term representations},
author = {Claudia Clopath and Tobias Bonhoeffer and Mark Hübener and Tobias Rose},
url = {https://doi.org/10.1098/rstb.2016.0161},
doi = {10.1098/rstb.2016.0161},
year = {2017},
date = {2017-03-01},
journal = {Philosophical Transactions of the Royal Society B: Biological Sciences},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1098/rstb.2016.0161
  • doi:10.1098/rstb.2016.0161

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Keck, Tara; Toyoizumi, Taro; Chen, Lu; Doiron, Brent; Feldman, Daniel E.; Fox, Kevin; Gerstner, Wulfram; Haydon, Philip G.; Hübener, Mark; Lee, Hey-Kyoung; Lisman, John E.; Rose, Tobias; Sengpiel, Frank; Stellwagen, David; Stryker, Michael P.; Turrigiano, Gina G.; Rossum, Mark C.

Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions Journal Article

In: Philosophical Transactions of the Royal Society B: Biological Sciences, 2017.

Links | BibTeX

@article{Keck2017Integrating,
title = {Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions},
author = {Tara Keck and Taro Toyoizumi and Lu Chen and Brent Doiron and Daniel E. Feldman and Kevin Fox and Wulfram Gerstner and Philip G. Haydon and Mark Hübener and Hey-Kyoung Lee and John E. Lisman and Tobias Rose and Frank Sengpiel and David Stellwagen and Michael P. Stryker and Gina G. Turrigiano and Mark C. Rossum},
url = {https://doi.org/10.1098/rstb.2016.0158},
doi = {10.1098/rstb.2016.0158},
year = {2017},
date = {2017-03-01},
journal = {Philosophical Transactions of the Royal Society B: Biological Sciences},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1098/rstb.2016.0158
  • doi:10.1098/rstb.2016.0158

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2016

Rose, Tobias; Jaepel, Juliane; Hübener, Mark; Bonhoeffer, Tobias

Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex Journal Article

In: Science, 2016.

Links | BibTeX

@article{Rose2016Cellspecific,
title = {Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex},
author = {Tobias Rose and Juliane Jaepel and Mark Hübener and Tobias Bonhoeffer},
url = {https://doi.org/10.1126/science.aad3358},
doi = {10.1126/science.aad3358},
year = {2016},
date = {2016-06-01},
journal = {Science},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1126/science.aad3358
  • doi:10.1126/science.aad3358

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2014

Rose, Tobias; Goltstein, Pieter M.; Portugues, Ruben; Griesbeck, Oliver

Putting a finishing touch on GECIs Journal Article

In: Frontiers in Molecular Neuroscience, 2014.

Links | BibTeX

@article{Rose2014Putting,
title = {Putting a finishing touch on GECIs},
author = {Tobias Rose and Pieter M. Goltstein and Ruben Portugues and Oliver Griesbeck},
url = {https://doi.org/10.3389/fnmol.2014.00088},
doi = {10.3389/fnmol.2014.00088},
year = {2014},
date = {2014-11-01},
journal = {Frontiers in Molecular Neuroscience},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.3389/fnmol.2014.00088
  • doi:10.3389/fnmol.2014.00088

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Marciniak, Anja; Cohrs, Christian M; Tsata, Vasiliki; Chouinard, Julie A; Selck, Claudia; Stertmann, Julia; Reichelt, Saskia; Rose, Tobias; Ehehalt, Florian; Weitz, Jürgen; Solimena, Michele; Rupnik, Marjan Slak; Speier, Stephan

Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology Journal Article

In: Nature Protocols, 2014.

Links | BibTeX

@article{Marciniak2014Using,
title = {Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology},
author = {Anja Marciniak and Christian M Cohrs and Vasiliki Tsata and Julie A Chouinard and Claudia Selck and Julia Stertmann and Saskia Reichelt and Tobias Rose and Florian Ehehalt and Jürgen Weitz and Michele Solimena and Marjan Slak Rupnik and Stephan Speier},
url = {https://doi.org/10.1038/nprot.2014.195},
doi = {10.1038/nprot.2014.195},
year = {2014},
date = {2014-11-01},
journal = {Nature Protocols},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1038/nprot.2014.195
  • doi:10.1038/nprot.2014.195

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2013

Rose, Tobias; Schoenenberger, Philipp; Jezek, Karel; Oertner, Thomas G.

Developmental Refinement of Vesicle Cycling at Schaffer Collateral Synapses Journal Article

In: Neuron, 2013.

Links | BibTeX

@article{Rose2013Developmental,
title = {Developmental Refinement of Vesicle Cycling at Schaffer Collateral Synapses},
author = {Tobias Rose and Philipp Schoenenberger and Karel Jezek and Thomas G. Oertner},
url = {https://doi.org/10.1016/j.neuron.2013.01.021},
doi = {10.1016/j.neuron.2013.01.021},
year = {2013},
date = {2013-03-01},
journal = {Neuron},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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  • https://doi.org/10.1016/j.neuron.2013.01.021
  • doi:10.1016/j.neuron.2013.01.021

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